Human oligodendrocyte lineage transcription factor 2 ELISA Kit | OLIG2 elisa kit
Human Oligodendrocyte transcription factor 2, OLIG2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Uniprot Description
OLIG2: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; DNA binding
Biological Process: transcription from RNA polymerase II promoter; myelination; negative regulation of neuron differentiation; spinal cord oligodendrocyte cell fate specification; neuron fate commitment; negative regulation of transcription from RNA polymerase II promoter; thalamus development; positive regulation of oligodendrocyte differentiation; spinal cord motor neuron differentiation
Research Articles on OLIG2
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Product Notes
The Human OLIG2 olig2 (Catalog #AAA9328698) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328698 ELISA Kit recognizes Human OLIG2. It is sometimes possible for the material contained within the vial of "oligodendrocyte lineage transcription factor 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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