OGN/Osteoglycin Recombinant Protein | OGN recombinant protein

OGN/Osteoglycin Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121421

• Gene Names: OGN; OG; OIF; SLRR3A
• Purity: >95% as determined by SDS-PAGE
• Synonyms: OGN/Osteoglycin; OGN/Osteoglycin Protein; Human; Recombinant (His Tag); Human OGN/osteoglycin protein (His Tag); OG Protein; OIF Protein; SLRR3A Protein; osteoglycin; OGN recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Phe298

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Pro 21
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human OGN (NP_054776.1)(Met1-Phe298) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for OGN recombinant protein

Background: OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epithelial-mesenchymal transition. In vitro and in vivo, the OGN expression was demonstrated to reduce cell proliferation, inhibit invasion of colon cancer cells then impede cancer progression. Diseases associated with OGN include Inhibited Male Orgasm and Cornea Plana.

NCBI and Uniprot Product Information

• NCBI GI #: 7661704
• NCBI GeneID: 4969
• NCBI Accession #: NP_054776.1
• NCBI GenBank Nucleotide #: NM_014057.4
• UniProt Accession #: P20774; Q6FIB0; Q9UF90; Q9UNK5
• Molecular Weight: 33,922 Da
• NCBI Official Full Name: mimecan isoform 2
• NCBI Official Synonym Full Names: osteoglycin
• NCBI Official Symbol: OGN
• NCBI Official Synonym Symbols: OG; OIF; SLRR3A
• NCBI Protein Information: mimecan
• UniProt Protein Name: Mimecan
• Protein Family: Mimecan
• UniProt Gene Name: OGN
• UniProt Synonym Gene Names: OIF; SLRR3A; OIF
• UniProt Entry Name: MIME_HUMAN

NCBI Description

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

OGN: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region; vesicle

Molecular Function: protein binding; growth factor activity

Biological Process: keratan sulfate metabolic process; glycosaminoglycan metabolic process; negative regulation of smooth muscle cell proliferation; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process