Mouse obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ELISA Kit | OBSCN elisa kit
Mouse Obscurin, OBSCN ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 800 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein is one of three giant sacromeric signaling proteins that includes titin and nebulin. It may have a role in the organization of myofibrils during assembly and also may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been described although the full-length nature is not known for all splicing variants. [provided by RefSeq, Jan 2010]
Uniprot Description
OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; CAMK group; Trio family
Cellular Component: sarcomere; striated muscle thick filament; M band; Z disc
Molecular Function: calmodulin binding; transferase activity; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; titin binding; ankyrin binding; kinase activity; ATP binding; protein kinase activity
Biological Process: multicellular organismal development; regulation of Rho protein signal transduction; cell differentiation; protein amino acid phosphorylation; phosphorylation
Research Articles on OBSCN
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Product Notes
The Mouse OBSCN obscn (Catalog #AAA9334881) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334881 ELISA Kit recognizes Mouse OBSCN. It is sometimes possible for the material contained within the vial of "obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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