Mouse ornithine decarboxylase antizyme 2 ELISA Kit | OAZ2 elisa kit
Mouse Ornithine decarboxylase antizyme 2, OAZ2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014]
Uniprot Description
OAZ2: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.
Protein type: Inhibitor
Cellular Component: nucleus; cytosol
Molecular Function: enzyme inhibitor activity; protein binding; ornithine decarboxylase inhibitor activity
Biological Process: polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; polyamine metabolic process
Research Articles on OAZ2
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Product Notes
The Mouse OAZ2 oaz2 (Catalog #AAA9323470) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323470 ELISA Kit recognizes Mouse OAZ2. It is sometimes possible for the material contained within the vial of "ornithine decarboxylase antizyme 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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