Nuclear pore complex protein Nup50 (NUP50) Recombinant Protein | NUP50 recombinant protein

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)

Cat. Num. AAA1433733

• Gene Names: NUP50; NPAP60; NPAP60L
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Nuclear pore complex protein Nup50 (NUP50); Recombinant Human Nuclear pore complex protein Nup50 (NUP50); NUP50 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-468, Full length protein
• Sequence: MAKRNAEKELTDRNWDQEDEAEEVGTFSMASEEVLKNRAIKKAKRRNVGFESDTGGAFKGFKGLVVPSGGGRFSGFGSGAGGKPLEGLSNGNNITSAPPFASAKAAADPKVAFGSLAANGPTTLVDKVSNPKTNGDSQQPSSSGLASSKACVGNAYHKQLAALNCSVRDWIVKHVNTNPLCDLTPIFKDYEKYLANIEQQHGNSGRNSESESNKVAAETQSPSLFGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPSSLGATSASFNFGKKVDSSVLGSLSSVPLTGFSFSPGNSSLFGKDTTQSKPVSSPFPTKPLEGQAEGDSGECKGGDEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGIGTLHLKPTANQKTQLLVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPIDEKNATMPVTMLIRVKTSEDADELHKILLEKKDA
• Sequence Length: 468

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for NUP50 recombinant protein

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This protein is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 24497451
• NCBI GeneID: 10762
• NCBI Accession #: NP_009103.2
• NCBI GenBank Nucleotide #: NM_007172.3
• UniProt Accession #: Q9UKX7; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; B1AHA4; B2RB15
• Molecular Weight: 46,863 Da
• NCBI Official Full Name: nuclear pore complex protein Nup50 isoform b
• NCBI Official Synonym Full Names: nucleoporin 50
• NCBI Official Symbol: NUP50
• NCBI Official Synonym Symbols: NPAP60; NPAP60L
• NCBI Protein Information: nuclear pore complex protein Nup50
• UniProt Protein Name: Nuclear pore complex protein Nup50
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP50
• UniProt Synonym Gene Names: NPAP60L

NCBI Description

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (). This interaction is required for correct intracellular transport and degradation of CDKN1B ().