Nudix Type Motif 3 Recombinant Protein | NUDT3 recombinant protein

Recombinant Human Nudix Type Motif 3

Cat. Num. AAA144879

• Gene Names: NUDT3; DIPP; DIPP1; DIPP-1
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Nudix Type Motif 3; Recombinant Human Nudix Type Motif 3; NUDT3 Human; Nudix Type Motif 3 Human Recombinant; Diphosphoinositol polyphosphate phosphohydrolase 1; DIPP-1; Diadenosine 5'; 5'''-P1; P6-hexaphosphate hydrolase 1; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3; NUDT3; DIPP; DIPP1; NUDT3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The NUDT3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
• Sequence Length: 172

Related Product Information for NUDT3 recombinant protein

Description: NUDT3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 21.6kDa. The NUDT3 is purified by proprietary chromatographic techniques.

Introduction: NUDT3 is a 172 amino acid cytoplasmic protein which is a member of the nudix hydrolase family and DIPP subfamily. NUDT3 functions as a negative regulator of the ERK 1/2 pathway and hydrolyzes 5-phosphoribose 1-diphosphate. NUDT3 is a monomer which binds magnesium as a cofactor. In addition, NUDT3 is widely expressed but can be found at highest levels in the liver, pancreas, brain and heart.

Product Categories/Family for NUDT3 recombinant protein

Enzymes; Nudix Type Motif

NCBI and Uniprot Product Information

• NCBI GI #: 5729804
• NCBI GeneID: 11165
• NCBI Accession #: NP_006694.1
• NCBI GenBank Nucleotide #: NM_006703.3
• UniProt Accession #: O95989; B2R8N4
• Molecular Weight: 19,471 Da
• NCBI Official Full Name: diphosphoinositol polyphosphate phosphohydrolase 1
• NCBI Official Synonym Full Names: nudix (nucleoside diphosphate linked moiety X)-type motif 3
• NCBI Official Symbol: NUDT3
• NCBI Official Synonym Symbols: DIPP; DIPP1; DIPP-1
• NCBI Protein Information: diphosphoinositol polyphosphate phosphohydrolase 1; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; nucleoside diphosphate-linked moiety X motif 3; nudix motif 3
• UniProt Protein Name: Diphosphoinositol polyphosphate phosphohydrolase 1
• Protein Family: Diphosphoinositol polyphosphate phosphohydrolase
• UniProt Gene Name: NUDT3
• UniProt Synonym Gene Names: DIPP; DIPP1; DIPP-1; Nudix motif 3
• UniProt Entry Name: NUDT3_HUMAN

NCBI Description

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

Uniprot Description

NUDT3: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily.

Protein type: Hydrolase; EC 3.6.1.52

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: cytosol

Molecular Function: magnesium ion binding; diphosphoinositol-polyphosphate diphosphatase activity

Biological Process: inositol phosphate metabolic process; cell-cell signaling; diadenosine polyphosphate catabolic process