NUDC recombinant protein

NUDC Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121803

• Gene Names: NUDC; HNUDC; MNUDC; NPD011
• Purity: >95% as determined by SDS-PAGE
• Synonyms: NUDC; NUDC Protein; Human; Recombinant (His Tag); Human NUDC Protein (His Tag); HNUDC Protein; MNUDC Protein; NPD011 Protein; nudC nuclear distribution protein; NUDC recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, 20% glycerol, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn331

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Met
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human NUDC (NP_006591.1)(Met1-Asn331) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for NUDC recombinant protein

Background: NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic region spans about 8 kb. NUDC was mapped to 1p34-p35 by fluorescence in situ hybridization. This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. Nuclear migration is essential for the growth, development, and cellular function of eukaryotes. NUDC protein plays an important role in nuclear migration. It is widely expressed in the testis, adrenal, and other tissues. NUDC protein is expressed highly in CNE-2 and HNE-2 cells. Anti-NUDC antibody could inhibit the growth of CNE-2 and HNE-2 cells.

NCBI and Uniprot Product Information

• NCBI GI #: 5729953
• NCBI GeneID: 10726
• NCBI Accession #: NP_006591.1
• NCBI GenBank Nucleotide #: NM_006600.3
• UniProt Accession #: Q9Y266; Q5QP31; Q5QP35; Q9H0N2; Q9Y2B6
• Molecular Weight: 38,243 Da
• NCBI Official Full Name: nuclear migration protein nudC
• NCBI Official Synonym Full Names: nuclear distribution C homolog (A. nidulans)
• NCBI Official Symbol: NUDC
• NCBI Official Synonym Symbols: HNUDC; MNUDC; NPD011
• NCBI Protein Information: nuclear migration protein nudC; nuclear distribution gene C homolog; nuclear distribution protein C homolog
• UniProt Protein Name: Nuclear migration protein nudC
• Protein Family: NADH pyrophosphatase
• UniProt Gene Name: NUDC
• UniProt Entry Name: NUDC_HUMAN

NCBI Description

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

Uniprot Description

NUDC: a cytoskeletal protein that is a component of the dynactin complex. The cytoplasmic dynein/dynactin complex, a minus-end-directed motor, powers various) aspects of mitosis, including establishment of bipolarity, organization of spindle poles, alignment and segregation of chromosomes, as well as regulation of microtubule dynamics. Phosphorylation by PLK1 may play a critical role in cytokinesis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: nucleoplasm; microtubule; cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: cell proliferation; mitosis; cell division; multicellular organismal development; mitotic cell cycle