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NUCB2 recombinant protein

NUCB2, Recombinant, Mouse (DNA-binding Protein NEFA, Nucleobindin-2, Nesfatin)

Gene Names
NUCB2; NEFA
Purity
Highly Purified
>90% (SDS-PAGE)
Synonyms
NUCB2; Recombinant; Mouse (DNA-binding Protein NEFA; Nucleobindin-2; Nesfatin); NUCB2 recombinant protein
Ordering
For Research Use Only!
Host
Mouse, E Coli
Purity/Purification
Highly Purified
>90% (SDS-PAGE)
Form/Format
Supplied as a 0.2um-filtered solution in PBS, pH 7.2.
Sequence
Human NUCB2 (aa 25-420) is fused at the C-terminus to a His-tag.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Working aliquots are stable for up to 3 months when stored at -20 degree C.
Related Product Information for NUCB2 recombinant protein
Nucelobindin-2 (NUCB2; Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite.
Product Categories/Family for NUCB2 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~55kD (SDS-PAGE)
NCBI Official Full Name
nucleobindin-2
NCBI Official Synonym Full Names
nucleobindin 2
NCBI Official Symbol
NUCB2
NCBI Official Synonym Symbols
NEFA
NCBI Protein Information
nucleobindin-2; nesfatin-1; prepronefastin; prepronesfatin; nucleobinding 2; DNA-binding protein NEFA; gastric cancer antigen Zg4
UniProt Protein Name
Nucleobindin-2
Protein Family
UniProt Gene Name
NUCB2
UniProt Synonym Gene Names
NEFA
UniProt Entry Name
NUCB2_HUMAN

NCBI Description

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

Uniprot Description

NUCB2: Calcium-binding protein. May have a role in calcium homeostasis. Belongs to the nucleobindin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Vesicle; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; plasma membrane; ER-Golgi intermediate compartment; nuclear envelope; cytosol

Molecular Function: protein binding; DNA binding; calcium ion binding

Research Articles on NUCB2

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Product Notes

The NUCB2 nucb2 (Catalog #AAA637959) is a Recombinant Protein produced from Mouse, E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Human NUCB2 (aa 25-420) is fused at the C-terminus to a His-tag. It is sometimes possible for the material contained within the vial of "NUCB2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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