Human negative regulator of ubiquitin-like proteins 1 ELISA Kit | NUB1 elisa kit
Human NEDD8 ultimate buster 1, NUB1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
NYREN18: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination
Research Articles on NUB1
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Product Notes
The Human NUB1 nub1 (Catalog #AAA9322915) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322915 ELISA Kit recognizes Human NUB1. It is sometimes possible for the material contained within the vial of "negative regulator of ubiquitin-like proteins 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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