High affinity nerve growth factor receptor (Ntrk1) Recombinant Protein | Ntrk1 recombinant protein

Recombinant Rat High affinity nerve growth factor receptor (Ntrk1)

• Gene Names: Ntrk1; Trk
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: High affinity nerve growth factor receptor (Ntrk1); Recombinant Rat High affinity nerve growth factor receptor (Ntrk1); High affinity nerve growth factor receptor; EC=2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Ntrk1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 33-418
• Sequence: AASCRETC CPVGPSGLRC TRAGTLNTLR GLRGAGNLTE LYVENQRDLQ RLEFEDLQGL GELRSLTIVK SGLRFVAPDA FHFTPRLSHL NLSSNALESL SWKTVQGLSL QDLTLSGNPL HCSCALLWLQ RWEQEDLCGV YTQKLQGSGS GDQFLPLGHN NSCGVPSVKI QMPNDSVEVG DDVFLQCQVE GQALQQADWI LTELEGTATM KKSGDLPSLG LTLVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGKAVEQHH WCIPFSVDGQ PAPSLRWFFN GSVLNETSFI FTQFLESALT NETMRHGCLR LNQPTHVNNG NYTLLAANPY GQAAASIMAA FMDNPFEFNP EDPIPVSFSP VDTNSTSRDP VEKKDETP
• Sequence Length: 386

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 11024666
• NCBI GeneID: 59109
• NCBI Accession #: NP_067600.1
• NCBI GenBank Nucleotide #: NM_021589.1
• UniProt Accession #: P35739
• Molecular Weight: 87,252 Da
• NCBI Official Full Name: high affinity nerve growth factor receptor
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 1
• NCBI Official Symbol: Ntrk1
• NCBI Official Synonym Symbols: Trk
• NCBI Protein Information: high affinity nerve growth factor receptor; trk; trk-A; p140-TrkA; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; slow nerve growth factor receptor
• UniProt Protein Name: High affinity nerve growth factor receptor
• Protein Family: High affinity nerve growth factor receptor
• UniProt Gene Name: Ntrk1
• UniProt Synonym Gene Names: Trk; Trka; Trk-A
• UniProt Entry Name: NTRK1_RAT

NCBI Description

a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]

Uniprot Description

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Oncoprotein; TK group; Trk family

Cellular Component: cell surface; protein complex; late endosome membrane; integral to plasma membrane; early endosome; dendrite; Golgi membrane; cell soma; early endosome membrane; axon; cytoplasm; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex

Molecular Function: neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; nerve growth factor receptor activity; ephrin receptor binding; protein-tyrosine kinase activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; kinase binding; ATP binding

Biological Process: circadian rhythm; response to nicotine; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; sensory perception of pain; olfactory nerve development; protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; sympathetic nervous system development; response to radiation; learning and/or memory; response to axon injury; negative regulation of neuron apoptosis; response to electrical stimulus; detection of temperature stimulus involved in sensory perception of pain; response to hydrostatic pressure; aging; response to drug; response to nutrient levels; nervous system development; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of angiogenesis; positive regulation of programmed cell death; response to ethanol; B cell differentiation; positive regulation of Ras protein signal transduction; response to activity