High affinity nerve growth factor receptor Recombinant Protein | NTRK1 recombinant protein
High affinity nerve growth factor receptor
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Uniprot Description
TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.
Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; Oncoprotein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: early endosome; endosome; integral to plasma membrane; late endosome; plasma membrane; protein complex; receptor complex
Molecular Function: nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; microtubule-based movement; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; protein amino acid autophosphorylation; protein amino acid phosphorylation; sympathetic nervous system development
Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary
Research Articles on NTRK1
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Product Notes
The NTRK1 ntrk1 (Catalog #AAA7043166) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 33-796aa; full length protein. The amino acid sequence is listed below: AAPCPDACCP HGSSGLRCTR DGALDSLHHL PGAENLTELY IENQQHLQHL ELRDLRGLGE LRNLTIVKSG LRFVAPDAFH FTPRLSRLNL SFNALESLSW KTVQGLSLQE LVLSGNPLHC SCALRWLQRW EEEGLGGVPE QKLQCHGQGP LAHMPNASCG VPTLKVQVPN ASVDVGDDVL LRCQVEGRGL EQAGWILTEL EQSATVMKSG GLPSLGLTLA NVTSDLNRKN VTCWAENDVG RAEVSVQVNV SFPASVQLHT AVEMHHWCIP FSVDGQPAPS LRWLFNGSVL NETSFIFTEF LEPAANETVR HGCLRLNQPT HVNNGNYTLL AANPFGQASA SIMAAFMDNP FEFNPEDPIP VSFSPVDTNS TSGDPVEKKD ETPFGVSVAV GLAVFACLFL STLLLVLNKC GRRNKFGINR PAVLAPEDGL AMSLHFMTLG GSSLSPTEGK GSGLQGHIIE NPQYFSDACV HHIKRRDIVL KWELGEGAFG KVFLAECHNL LPEQDKMLVA VKALKEASES ARQDFQREAE LLTMLQHQHI VRFFGVCTEG RPLLMVFEYM RHGDLNRFLR SHGPDAKLLA GGEDVAPGPL GLGQLLAVAS QVAAGMVYLA GLHFVHRDLA TRNCLVGQGL VVKIGDFGMS RDIYSTDYYR VGGRTMLPIR WMPPESILYR KFTTESDVWS FGVVLWEIFT YGKQPWYQLS NTEAIDCITQ GRELERPRAC PPEVYAIMRG CWQREPQQRH SIKDVHARLQ ALAQAPPVYL DVLG. It is sometimes possible for the material contained within the vial of "High affinity nerve growth factor receptor, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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