Mitochondrial DNA base excision repair N-glycosylase 1 (NTG1) Recombinant Protein | NTG1 recombinant protein
Recombinant Saccharomyces cerevisiae Mitochondrial DNA base excision repair N-glycosylase 1 (NTG1)
NCBI and Uniprot Product Information
Uniprot Description
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage and cytosine photoproducts generated by UV irradiation as well as abasic sites. Has also 8-oxoguanine DNA glycosylase activity. The AP lyase can incise AP sites opposite all four bases. May also play a role in the regulation of mtDNA copy number by introducing a double-stranded break (DSB) at the mtDNA replication origin ori5, initiating the rolling-circle mtDNA replication.
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Product Notes
The NTG1 ntg1 (Catalog #AAA1049065) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-399, full length protein. The amino acid sequence is listed below: LVKTETGPES ELLPEKRTKI KQEEVVPQPV DIDWVKSLPN KQYFEWIVVR NGNVPNRWAT PLDPSILVTP ASTKVPYKFQ ETYARMRVLR SKILAPVDII GGSSIPVTVA SKCGISKEQI SPRDYRLQVL LGVMLSSQTK DEVTAMAMLN IMRYCIDELH SEEGMTLEAV LQINETKLDE LIHSVGFHTR KAKYILSTCK ILQDQFSSDV PATINELLGL PGVGPKMAYL TLQKAWGKIE GICVDVHVDR LTKLWKWVDA QKCKTPDQTR TQLQNWLPKG LWTEINGLLV GFGQIITKSR NLGDMLQFLP PDDPRSSLDW DLQSQLYKEI QQNIMSYPKW VKYLEGKREL NVEAEINVKH EEKTVEETMV KLENDISVKV ED. It is sometimes possible for the material contained within the vial of "Mitochondrial DNA base excision repair N-glycosylase 1 (NTG1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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