Neuronal cell adhesion molecule (Nrcam) Recombinant Protein | Nrcam recombinant protein

Recombinant Rat Neuronal cell adhesion molecule (Nrcam) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Neuronal cell adhesion molecule (Nrcam); Recombinant Rat Neuronal cell adhesion molecule (Nrcam); partial; Nrcam recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,183

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Nrcam recombinant protein

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 38372401
• NCBI GeneID: 497815
• UniProt Accession #: P97686
• Molecular Weight: 130,831 Da
• NCBI Official Full Name: Neuronal cell adhesion molecule
• NCBI Official Synonym Full Names: neuronal cell adhesion molecule
• NCBI Official Symbol: Nrcam
• NCBI Protein Information: neuronal cell adhesion molecule
• UniProt Protein Name: Neuronal cell adhesion molecule
• Protein Family: Neuronal cell adhesion molecule
• UniProt Gene Name: Nrcam
• UniProt Synonym Gene Names: Nr-CAM; rBravo; Ng-CAM-related

NCBI Description

a neuronal cell adhesion molecule localized at the node of Ranvier of myelinated axons [RGD, Feb 2006]

Uniprot Description

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons (). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.