Glucocorticoid receptor (NR3C1) Recombinant Protein | NR3C1 recombinant protein

Recombinant Guinea pig Glucocorticoid receptor (NR3C1), partial

• Gene Names: Nr3c1; GRL
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Glucocorticoid receptor (NR3C1); Recombinant Guinea pig Glucocorticoid receptor (NR3C1); partial; NR3C1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 771

• Species: Cavia porcellus (Guinea pig)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for NR3C1 recombinant protein

This protein is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 290565151
• NCBI GeneID: 100135583
• NCBI Accession #: NP_001166458.1
• NCBI GenBank Nucleotide #: NM_001172987.1
• UniProt Accession #: P49115
• Molecular Weight: 84,862 Da
• NCBI Official Full Name: glucocorticoid receptor
• NCBI Official Symbol: Nr3c1
• NCBI Official Synonym Symbols: GRL
• NCBI Protein Information: glucocorticoid receptor
• UniProt Protein Name: Glucocorticoid receptor
• Protein Family: Glucocorticoid receptor
• UniProt Gene Name: NR3C1
• UniProt Synonym Gene Names: GRL; GR

Uniprot Description

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.