Typical Testing Data/Standard Curve (for reference only)
Mouse Bile acid receptor ELISA Kit | Nr1h4 elisa kit
Mouse Bile acid receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
NR1H4: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2. Interacts with CARM1 and SMARD1. Belongs to the nuclear hormone receptor family. NR1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor; DNA-binding
Cellular Component: nucleus
Molecular Function: bile acid binding; DNA binding; double-stranded DNA binding; ligand-dependent nuclear receptor activity; metal ion binding; peptide binding; receptor activity; retinoid X receptor binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; zinc ion binding
Biological Process: bile acid metabolic process; defense response to bacterium; fatty acid homeostasis; glucose homeostasis; intercellular junction assembly; intracellular receptor-mediated signaling pathway; negative regulation of apoptosis; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent
Research Articles on Nr1h4
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Product Notes
The Mouse Nr1h4 nr1h4 (Catalog #AAA2880847) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880847 ELISA Kit recognizes Mouse Nr1h4. It is sometimes possible for the material contained within the vial of "Bile acid receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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