Rat NAD (P) H dehydrogenase, quinone 1 ELISA Kit | NQO1 elisa kit
Rat NAD (P) H dehydrogenase [quinone] 1
NCBI and Uniprot Product Information
NCBI Description
enzyme that acts as an antioxidant; involved in increasing neuronal damage after injury [RGD, Feb 2006]
Uniprot Description
NQO1: a FAD-binding flavoprotein enzyme that that prevents the one electron reduction of quinones that results in the production of radical species. Involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Mutations have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer (NSCLC) compared with the normal tissues. Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQ01 in the prevention of tumor development. A homozygous common missense variant (NQO1(*)2, rs1800566(T)), that disables NQO1 strongly predicts poor survival among two independent series of women with breast cancer. Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turn leads to myeloid hyperplasia of bone marrow. Altered expression is associated with Alzheimer's disease (AD). Inhibited by dicoumarol. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.6.5.2; Oxidoreductase
Cellular Component: cell soma; cytoplasm; cytosol
Molecular Function: identical protein binding; NAD(P)H dehydrogenase (quinone) activity; superoxide dismutase activity
Biological Process: response to ethanol; removal of superoxide radicals; positive regulation of neuron apoptosis; negative regulation of catalytic activity; superoxide metabolic process; response to oxidative stress; response to organic cyclic substance; response to estradiol stimulus; response to nutrient; aging
Research Articles on NQO1
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Product Notes
The Rat NQO1 nqo1 (Catalog #AAA9337618) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337618 ELISA Kit recognizes Rat NQO1. It is sometimes possible for the material contained within the vial of "NAD (P) H dehydrogenase, quinone 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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