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Neuropeptide Y Receptor Y4 Assay System | NPY4R assay system

Neuropeptide Y Receptor Y4 (NPY4R) ACTOne Stable Cell Line

Gene Names
NPY4R; Y4; PP1; PPYR1; NPY4-R
Synonyms
Neuropeptide Y Receptor Y4; Neuropeptide Y Receptor Y4 (NPY4R) ACTOne Stable Cell Line; Neuropeptide Y Receptor Y4 (NPY4R) ACTOneTM Stable Cell Line; NPY4R assay system
Ordering
Sequence Length
375
Application Notes
cAMP dependent assay for Gi-coupled human NPY1R; cell-based high-throughput screening of human NPY1R inhibitors
Preparation and Storage
Product is shipped on dry ice. Storage: Remove the frozen cells from the dry ice packaging and immediately place the cells at a temperature below -130 degrees C preferably in liquid nitrogen vapor, until ready for use.
Related Product Information for NPY4R assay system
Background/Introduction: Neuropeptide Y receptor Y4 (NPY4R), also called pancreatic polypeptide receptor 1 (PPYR1), is a member of the Gi/o-protein-coupled receptor family that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42,195 Da
NCBI Official Full Name
neuropeptide Y receptor type 4
NCBI Official Synonym Full Names
neuropeptide Y receptor Y4
NCBI Official Symbol
NPY4R
NCBI Official Synonym Symbols
Y4; PP1; PPYR1; NPY4-R
NCBI Protein Information
neuropeptide Y receptor type 4; pancreatic polypeptide receptor 1
UniProt Protein Name
Neuropeptide Y receptor type 4
Protein Family
UniProt Gene Name
NPY4R
UniProt Entry Name
NPY4R_HUMAN

Uniprot Description

NPY4R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; peptide YY receptor activity; pancreatic polypeptide receptor activity; peptide binding

Biological Process: G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; blood circulation; digestion; feeding behavior

Research Articles on NPY4R

Similar Products

Product Notes

The NPY4R npy4r (Catalog #AAA433602) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent assay for Gi-coupled human NPY1R; cell-based high-throughput screening of human NPY1R inhibitors. Researchers should empirically determine the suitability of the NPY4R npy4r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuropeptide Y Receptor Y4, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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