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Brain Natriuretic Peptide (BNP) Recombinant Protein | BNP recombinant protein
Recombinant Brain Natriuretic Peptide (BNP)
MGHHHHHHSGSEF- YPLG SPSQSPEQFK MQKLLELIRE KSEEMAQRQL LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF GHKIDRIGSV SRLGCNALKL L
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Uniprot Description
NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
Protein type: Hormone; Secreted, signal peptide; Secreted
Cellular Component: extracellular space; protein complex; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus
Molecular Function: peptide hormone receptor binding; hormone activity
Biological Process: cGMP biosynthetic process; negative regulation of smooth muscle cell proliferation; regulation of blood pressure; negative regulation of systemic arterial blood pressure; negative regulation of cell growth; regulation of blood vessel size
Research Articles on BNP
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Product Notes
The BNP nppb (Catalog #AAA2009514) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Brain Natriuretic Peptide (BNP) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the BNP nppb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF- YPLG SPSQSPEQFK MQKLLELIRE KSEEMAQRQL LKDQGLTKEH PKRVLRSQGS TLRVQQRPQN SKVTHISSCF GHKIDRIGSV SRLGCNALKL L. It is sometimes possible for the material contained within the vial of "Brain Natriuretic Peptide (BNP), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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