Nuclear protein localization protein 4 homolog (Nploc4) Recombinant Protein | Nploc4 recombinant protein
Recombinant Mouse Nuclear protein localization protein 4 homolog (Nploc4)
Gene Names
Nploc4; Npl4; AK129375; mKIAA1499
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Nuclear protein localization protein 4 homolog (Nploc4); Recombinant Mouse Nuclear protein localization protein 4 homolog (Nploc4); Nploc4 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-608, Full length protein
Sequence
AESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT
Sequence Length
607
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
64,379 Da
NCBI Official Full Name
nuclear protein localization protein 4 homolog isoform A
NCBI Official Synonym Full Names
NPL4 homolog, ubiquitin recognition factor
NCBI Official Symbol
Nploc4
NCBI Official Synonym Symbols
Npl4; AK129375; mKIAA1499
NCBI Protein Information
nuclear protein localization protein 4 homolog
UniProt Protein Name
Nuclear protein localization protein 4 homolog
Protein Family
UniProt Gene Name
Nploc4
UniProt Synonym Gene Names
Kiaa1499; Npl4; Protein NPL4
Uniprot Description
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I ().
Research Articles on Nploc4
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Product Notes
The Nploc4 nploc4 (Catalog #AAA952930) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-608, Full length protein. The amino acid sequence is listed below: AESIIIRVQS PDGVKRITAT KRETAATFLK KVAKEFGFQN NGFSVYINRN KTGEITASSS KSLHLLKIKH GDLLFLFPSS LAGPSSEMET STSVGLKAFG APNVVEDEID QYLSKQDGKI YRSRDPQLCR HGPLGKCVHC VPLEPFDEDY LNHLEPPVKH MSFHAYIRKL TGGADKGKFV ALENISCKIK SGCEGHLPWP NGICTKCQPS AITLNRQKYR HVDNIMFENH TVADRFLDFW RKTGNQHFGY LYGRYTEHKD IPLGIRAEVA AIYEPPQIGT QNSLELLEDP KAEVVDEIAA KLGLRKVGWI FTDLVSEDTR KGTVRYSRNK DTYFLSSEEC ITAGDFQNKH PNICRLSPDG HFGSKFVTAV ATGGPDNQVH FEGYQVSNQC MALVRDECLL PCKDAPELGY AKESSSEQYV PDVFYKDIDK FGNEITQLAR PLPVEYLIID ITTTFPKDPV YTFSISQNPF PIENRDVLGE TQDFHSLATY LSQNTSSVFL DTISDFHLLL FLVTNEVMPL QDSISLLLEA VRTRNEELAQ TWKKSEQWAT IEQLCSTVGV QLPGLHEFGA VGGSARAATS AMWACQHCTF MNQPGTGHCE MCSLPRT. It is sometimes possible for the material contained within the vial of "Nuclear protein localization protein 4 homolog (Nploc4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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