Typical Testing Data/Standard Curve (for reference only)
Mouse Neurogenic locus notch homolog protein 4 ELISA Kit | Notch4 elisa kit
Mouse Neurogenic locus notch homolog protein 4 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
NOTCH4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4. Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes. Belongs to the NOTCH family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: cell surface; cytoplasmic vesicle; endoplasmic reticulum; integral to membrane; membrane; nucleus; plasma membrane
Molecular Function: calcium ion binding; Notch binding; protein binding
Biological Process: cell differentiation; embryonic development; endothelial cell differentiation; endothelial cell morphogenesis; mammary gland development; morphogenesis of a branching structure; multicellular organismal development; negative regulation of endothelial cell differentiation; negative regulation of Notch signaling pathway; Notch signaling pathway; patterning of blood vessels; positive regulation of angiogenesis; regulation of Notch signaling pathway; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on Notch4
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Product Notes
The Mouse Notch4 notch4 (Catalog #AAA2886403) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886403 ELISA Kit recognizes Mouse Notch4. It is sometimes possible for the material contained within the vial of "Neurogenic locus notch homolog protein 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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