NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Recombinant Protein | NOD1 recombinant protein
Human NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Recombinant Protein
Gene Names
NOD1; CARD4; NLRC1; CLR7.1
Applications
ELISA, Western Blot
Purity
>95% by SDS-PAGE
Synonyms
NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1; Human NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1 Recombinant Protein; Nucleotide-binding oligomerization domain-containing protein 1; Caspase recruitment domain-containing protein 4; CARD4; NOD1 recombinant protein
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
Concentration
Reconstitution Dependent (varies by lot)
Sequence Length
953
Applicable Applications for NOD1 recombinant protein
ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
Species
Human
Tag
His
Subunit
Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection. Interacts with RNF34.
Entry Function
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
Preparation and Storage
Store at -20 degree C. Avoid repeated freezing and thawing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
nucleotide-binding oligomerization domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
nucleotide binding oligomerization domain containing 1
NCBI Official Symbol
NOD1
NCBI Official Synonym Symbols
CARD4; NLRC1; CLR7.1
NCBI Protein Information
nucleotide-binding oligomerization domain-containing protein 1
UniProt Protein Name
Nucleotide-binding oligomerization domain-containing protein 1
Protein Family
UniProt Gene Name
NOD1
UniProt Synonym Gene Names
CARD4
UniProt Entry Name
NOD1_HUMAN
NCBI Description
This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
Research Articles on NOD1
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Product Notes
The NOD1 nod1 (Catalog #AAA2902589) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the NOD1 nod1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOD1 / Nucleotide-Binding Oligomerization Domain-Containing Protein 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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