NACHT, LRR and PYD domains-containing protein 6 (NLRP6) Recombinant Protein | NLRP6 recombinant protein

Recombinant Human NACHT, LRR and PYD domains-containing protein 6 (NLRP6) , partial

• Gene Names: NLRP6; AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: NACHT; LRR and PYD domains-containing protein 6 (NLRP6); Recombinant Human NACHT; partial; NLRP6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 891

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 452085173
• NCBI GeneID: 171389
• NCBI Accession #: NP_001263629.1
• NCBI GenBank Nucleotide #: NM_001276700.1
• UniProt Accession #: P59044; A8K9F3; E9PJZ8
• Molecular Weight: 98,681 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 6 isoform 2
• NCBI Official Synonym Full Names: NLR family pyrin domain containing 6
• NCBI Official Symbol: NLRP6
• NCBI Official Synonym Symbols: AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 6
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 6
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP6
• UniProt Synonym Gene Names: NALP6; PYPAF5

NCBI Description

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Description

As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet () (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism ().