NALP12 Blocking Peptide | NLRP12 blocking peptide

NALP12 Peptide

Cat. Num. AAA152009

• Gene Names: NLRP12; RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
• Applications: Blocking (BL)
• Synonyms: NALP12; NALP12 Peptide; RNO; PAN6; RNO2; FCAS2; PYPAF7; CLR19.3; NACHT; LRR and PYD domains-containing protein 12; Monarch-1; NLR family; pyrin domain containing 12; NLRP12 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1061

• Applicable Applications for NLRP12 blocking peptide: Blocking (BL)
• Application Notes: NALP12 peptide is used for blocking the activity of NALP12 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the amino terminus of human NALP12.
• Preparation and Storage: Store NALP12 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 21955154
• NCBI GeneID: 91662
• NCBI Accession #: NP_653288
• NCBI GenBank Nucleotide #: NM_144687.3
• UniProt Accession #: P59046; Q8NEU4; Q9BY26; A8MTQ2; B3KTE7
• Molecular Weight: 120,329 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 12 isoform 2
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 12
• NCBI Official Symbol: NLRP12
• NCBI Official Synonym Symbols: RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 12; monarch 1; regulated by nitric oxide; PYRIN-containing APAF1-like protein 7; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 12
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP12
• UniProt Synonym Gene Names: NALP12; PYPAF7; RNO
• UniProt Entry Name: NAL12_HUMAN

NCBI Description

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; caspase activator activity; ATP binding

Biological Process: caspase activation; release of cytoplasmic sequestered NF-kappaB; negative regulation of cytokine secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; signal transduction; regulation of caspase activity; negative regulation of signal transduction; negative regulation of Toll signaling pathway; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; negative regulation of protein amino acid autophosphorylation; positive regulation of MHC class I biosynthetic process; regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 secretion; regulation of interleukin-18 biosynthetic process; positive regulation of inflammatory response

Disease: Familial Cold Autoinflammatory Syndrome 2