KappaB ras1 Blocking Peptide | NKIRAS1 blocking peptide

KappaB ras1 Peptide

Cat. Num. AAA152288

• Gene Names: NKIRAS1; KBRAS1; kappaB-Ras1
• Applications: Blocking (BL)
• Synonyms: KappaB ras1; KappaB ras1 Peptide; KBRAS1; kappaB-Ras1; NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; NFKB inhibitor interacting Ras-like 1; NKIRAS1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 192

• Applicable Applications for NKIRAS1 blocking peptide: Blocking (BL)
• Application Notes: The peptide is used for blocking the activity of KappaB ras-1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 15 amino acids near the carboxy terminus of human KappaB ras-1
• Preparation and Storage: Store KappaB ras1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 7008402
• NCBI GeneID: 28512
• UniProt Accession #: Q9NYS0; Q96K18
• Molecular Weight: 21,643 Da
• NCBI Official Full Name: kappa B-ras 1
• NCBI Official Synonym Full Names: NFKB inhibitor interacting Ras-like 1
• NCBI Official Symbol: NKIRAS1
• NCBI Official Synonym Symbols: KBRAS1; kappaB-Ras1
• NCBI Protein Information: NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa B-ras 1; kappa B-Ras protein 1; I-kappa-B-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1
• UniProt Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• Protein Family: NF-kappa-B inhibitor-interacting Ras-like protein
• UniProt Gene Name: NKIRAS1
• UniProt Synonym Gene Names: KBRAS1; Kappa B-Ras protein 1; KappaB-Ras1
• UniProt Entry Name: KBRS1_HUMAN

Uniprot Description

NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: membrane; cytoplasm

Molecular Function: GTPase activity; GTP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; metabolic process; small GTPase mediated signal transduction