Ninjurin-1 / NINJ1 Recombinant Protein | NINJ1 recombinant protein
Recombinant Rat Ninjurin-1 / NINJ1 Protein (Fc tag)
Purity
> 95 % as determined by SDS-PAGE
Synonyms
Ninjurin-1 / NINJ1; Recombinant Rat Ninjurin-1 / NINJ1 Protein (Fc tag); NINJ1; NINJ1 recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
152
Application Notes
The recombinant rat NINJ1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 340 amino acids and has a calculated molecular mass of 37 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rat NINJ1/Fc monomer is approximately 50 kDa due to glycosylation.
Predicted N Terminal
Glu
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for NINJ1 recombinant protein
Background: Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19 (+) CD10 (+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in a number of other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and in Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified as a marker of minimal residual disease in B-lineage acute lymphoblastic leukemia. It mediates homophilic adhesion, and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin-1 has been found to show a high expression level in the liver tissue of patients with hepatocellular carcinoma, and this seems to be associated with cases of cirrhosis and chronic viral hepatitis. It has been reported that NINJURIN increases p21 expression and induces cellular senescence in human hepatoma cells.
Description: A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.
Description: A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16,539 Da
NCBI Official Full Name
ninjurin-1
NCBI Official Synonym Full Names
ninjurin 1
NCBI Official Symbol
Ninj1
NCBI Protein Information
ninjurin-1
UniProt Protein Name
Ninjurin-1
Protein Family
UniProt Gene Name
Ninj1
NCBI Description
adhesion molecule; promotes neurite extension of dorsal root ganglion [RGD, Feb 2006]
Uniprot Description
NINJ1: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. Belongs to the ninjurin family.
Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p14
Biological Process: positive regulation of cell-matrix adhesion
Research Articles on NINJ1
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Product Notes
The NINJ1 ninj1 (Catalog #AAA2547294) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat NINJ1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 340 amino acids and has a calculated molecular mass of 37 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rat NINJ1/Fc monomer is approximately 50 kDa due to glycosylation. Researchers should empirically determine the suitability of the NINJ1 ninj1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ninjurin-1 / NINJ1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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