IkappaB-epsilon ELISA Kit | NFKBIE elisa kit
Phospho-IkappaB-epsilon (Ser22) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Uniprot Description
IkB-epsilon: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytoplasm; cytosol; fibrillar center; Golgi apparatus; nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding
Biological Process: cytoplasmic sequestering of transcription factor; D-serine transport
Research Articles on NFKBIE
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Product Notes
The Human, Mouse, Rat NFKBIE nfkbie (Catalog #AAA9500978) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500978 ELISA Kit recognizes Human, Mouse, Rat NFKBIE. It is sometimes possible for the material contained within the vial of "IkappaB-epsilon, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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