Human Microtubule-associated protein RP/EB family member 1 ELISA Kit | MAPRE1 elisa kit

Human Microtubule-associated protein RP/EB family member 1 ELISA Kit

Cat. Num. AAA289263

• Gene Names: MAPRE1; EB1
• Reactivity: Human
• Synonyms: Microtubule-associated protein RP/EB family member 1; Human Microtubule-associated protein RP/EB family member 1 ELISA Kit; APC-binding protein EB1; End-binding protein 1; EB1; MAPRE1; MAPRE1 elisa kit

• Reactivity: Human
• Sequence Length: 268

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.089 ng/mL
• Intra-Assay CV: <=7.3%
• Inter-Assay CV: <=10.2%
• Recovery: 91%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6912494
• NCBI GeneID: 22919
• NCBI Accession #: NP_036457.1
• NCBI GenBank Nucleotide #: NM_012325.2
• UniProt Accession #: Q15691; Q3KQS8; B2R6I7; E1P5M8
• Molecular Weight: 29,999 Da
• NCBI Official Full Name: microtubule-associated protein RP/EB family member 1
• NCBI Official Synonym Full Names: microtubule associated protein RP/EB family member 1
• NCBI Official Symbol: MAPRE1
• NCBI Official Synonym Symbols: EB1
• NCBI Protein Information: microtubule-associated protein RP/EB family member 1
• UniProt Protein Name: Microtubule-associated protein RP/EB family member 1
• Protein Family: Microtubule-associated protein RP/EB family
• UniProt Gene Name: MAPRE1
• UniProt Synonym Gene Names: EB1
• UniProt Entry Name: MARE1_HUMAN

NCBI Description

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Uniprot Description

EB1: a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q11.1-q11.23

Cellular Component: cell projection membrane; centrosome; cortical microtubule cytoskeleton; cytoplasm; cytoplasmic microtubule; cytosol; Golgi apparatus; microtubule; spindle

Molecular Function: microtubule plus-end binding; protein binding; protein C-terminus binding

Biological Process: cell division; cell proliferation; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; negative regulation of microtubule polymerization; organelle organization and biogenesis; small GTPase mediated signal transduction