IKB beta/NFKBIB Recombinant Protein | NFKBIB recombinant protein

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8118680

• Gene Names: NFKBIB; IKBB; TRIP9
• Purity: >75 % as determined by SDS-PAGE.
• Synonyms: IKB beta/NFKBIB; IKB beta/NFKBIB Protein; Human; Recombinant (GST Tag); Human IKB beta/NFKBIB Protein (GST Tag); NFKB inhibitor beta; IKBB Protein; TRIP9 Protein; NFKBIB recombinant protein

• Host: E Coli
• Purity/Purification: >75 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, 20% glycerol, pH7.4 Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 601aa
• Sequence: Met1-Val356

• Species: Human
• Tag: N-GST
• Predicted N Terminal: Met
• Protein Construction: |A DNA sequence encoding the human NFKBIB (NP_002494.2) (Met1-Val356) was expressed with an N-terminal GST tag.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Testing Data

Related Product Information for NFKBIB recombinant protein

NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor protein NFKBIB, which form complexes with NF-kappaB to sequester it in the cytoplasm. Overexpression of NFKBIB protein in IAV infected cells led to lower levels of IAV. MiR-20a could promote activation of the NFkappaB pathway and downstream targets Livin and Survivin by targeting NFKBIB, which potentially contributed to GC chemoresistance.

Product Categories/Family for NFKBIB recombinant protein

Death Receptor Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 21361135
• NCBI GeneID: 4793
• NCBI Accession #: NP_002494.2
• NCBI GenBank Nucleotide #: NM_002503.4
• UniProt Accession #: Q15653; Q96BJ7; A8K3F4
• Molecular Weight: 35,530 Da
• NCBI Official Full Name: NF-kappa-B inhibitor beta isoform 1
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
• NCBI Official Symbol: NFKBIB
• NCBI Official Synonym Symbols: IKBB; TRIP9
• NCBI Protein Information: NF-kappa-B inhibitor beta; ikB-B; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB; I-kappa-B-beta; TR-interacting protein 9; thyroid receptor-interacting protein 9
• UniProt Protein Name: NF-kappa-B inhibitor beta
• Protein Family: NF-kappa-B inhibitor
• UniProt Gene Name: NFKBIB
• UniProt Synonym Gene Names: IKBB; TRIP9; NF-kappa-BIB; IkB-B; IkB-beta; IkappaBbeta; TR-interacting protein 9; TRIP-9
• UniProt Entry Name: IKBB_HUMAN

NCBI Description

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

IkB-beta: a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: nucleus; cytosol

Molecular Function: signal transducer activity; protein binding; transcription coactivator activity

Biological Process: transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; positive regulation of interferon type I production; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway