NF-kappaB p100/p52 ELISA Kit | NFKB2 elisa kit
Phospho-NF-kappaB p100/p52 (Ser865) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Description
NFkB-p100: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two spliced isoforms have been identified. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: Bcl3/NF-kappaB2 complex; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding transcription factor activity; protein binding; transcription coactivator activity
Biological Process: aging; extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; negative regulation of transcription from RNA polymerase II promoter; NIK/NF-kappaB signaling; positive regulation of interferon type I production; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to cytokine; response to lipopolysaccharide; rhythmic process; spleen development; transcription from RNA polymerase II promoter
Disease: Immunodeficiency, Common Variable, 10
Research Articles on NFKB2
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Product Notes
The Human, Mouse, Rat NFKB2 nfkb2 (Catalog #AAA9501518) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501518 ELISA Kit recognizes Human, Mouse, Rat NFKB2. It is sometimes possible for the material contained within the vial of "NF-kappaB p100/p52, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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