Nuclear factor erythroid 2-related factor 1 (Nfe2l1) Recombinant Protein | Nfe2l1 recombinant protein

Recombinant Mouse Nuclear factor erythroid 2-related factor 1 (Nfe2l1), partial

Cat. Num. AAA1479493

• Gene Names: Nfe2l1; NRF1; Lcrf1; TCF11; LCR-F1; TCF-11; AA408798; AW212678
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Nuclear factor erythroid 2-related factor 1 (Nfe2l1); Recombinant Mouse Nuclear factor erythroid 2-related factor 1 (Nfe2l1); partial; Nfe2l1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-741
• Sequence: MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR QDIDLGAGRE VFDYSHRQKE QDVDKELQDG REREDTWSGE GAEALARDLL VDGETGESFP AQFPADVSSI PEAVPSESES PALQNSLLSP LLTGTESPFD LEQQWQDLMS IMEMQAMEVN TSASEILYNA PPGDPLSTNY SLAPNTPINQ NVSLHQASLG GCSQDFSLFS PEVESLPVAS SSTLLPLVPS NSTSLNSTFG STNLAGLFFP SQLNGTANDT SGPELPDPLG GLLDEAMLDE ISLMDLAIEE GFNPVQASQL EEEFDSDSGL SLDSSHSPSS LSSSEGSSSS SSSSSSSSAS SSASSSFSEE GAVGYSSDSE TLDLEEAEGA VGYQPEYSKF CRMSYQDPSQ LSCLPYLEHV GHNHTYNMAP SALDSADLPP PSTLKKGSKE KQADFLDKQM SRDEHRARAM KIPFTNDKII NLPVEEFNEL LSKYQLSEAQ LSLIRDIRRR GKNKMAAQNC RKRKLDTILN LERDVEDLQR DKARLLREKV EFLRSLRQMK QKVQSLYQEV FGRLRDEHGR PYSPSQYALQ YAGDGSVLLI PRTMADQQAR RQERKPKDRR K
• Sequence Length: 741

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Nfe2l1 recombinant protein

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for nuclear respiratory factor 1 which has an official symbol of NRF1.

NCBI and Uniprot Product Information

• NCBI GI #: 194394181
• NCBI GeneID: 18023
• NCBI Accession #: NP_001123922.1
• NCBI GenBank Nucleotide #: NM_001130450.1
• UniProt Accession #: Q61985; O70234; E9Q038
• Molecular Weight: 35,158 Da
• NCBI Official Full Name: endoplasmic reticulum membrane sensor NFE2L1 isoform 1
• NCBI Official Synonym Full Names: nuclear factor, erythroid derived 2,-like 1
• NCBI Official Symbol: Nfe2l1
• NCBI Official Synonym Symbols: NRF1; Lcrf1; TCF11; LCR-F1; TCF-11; AA408798; AW212678
• NCBI Protein Information: endoplasmic reticulum membrane sensor NFE2L1; nuclear factor erythroid 2-related factor 1
• UniProt Protein Name: Endoplasmic reticulum membrane sensor NFE2L1
• Protein Family: Nuclear factor erythroid 2-related factor
• UniProt Gene Name: Nfe2l1
• UniProt Synonym Gene Names: NFE2-related factor 1

NCBI Description

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

Uniprot Description

Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). Constitutes a precursor of the transcription factor NRF1. Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (PubMed:29149604). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (PubMed:29149604). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20385086, PubMed:21536885, PubMed:23816881).