Mouse Endonuclease 8-like 3 ELISA Kit | Neil3 elisa kit
Mouse Endonuclease 8-like 3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NEIL3: Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single- stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected. Belongs to the FPG family.
Protein type: DNA-binding; EC 4.2.99.18
Chromosomal Location of Human Ortholog: 8|8 B1.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: bubble DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; single-stranded DNA binding
Biological Process: base-excision repair
Research Articles on Neil3
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Product Notes
The Mouse Neil3 neil3 (Catalog #AAA9428457) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9428457 ELISA Kit recognizes Mouse Neil3. It is sometimes possible for the material contained within the vial of "Endonuclease 8-like 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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