Nectin-3/PVRL3/CD113 Recombinant Protein | PVRL3/CD113 recombinant protein

Recombinant Human Nectin-3/PVRL3/CD113 Protein (C-6His)

Cat. Num. AAA2552993

• Gene Names: NECTIN3; PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Nectin-3/PVRL3/CD113; Recombinant Human Nectin-3/PVRL3/CD113 Protein (C-6His); Poliovirus Receptor-Related Protein 3; CDw113; Nectin-3; CD113; PVRL3; PRR3; PVRL3/CD113 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.
• Sequence Positions: Gly58-Cys366
• Sequence Length: 366

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for PVRL3/CD113 recombinant protein

Nectin-3 is a type I transmembrane glycoprotein that belongs to the nectin family. Its precursor is 549 amino acids in length and contains an extended signal sequence of 57 amino acids, an extracellular domain (ECD) of 347 amino acids, a transmembrane segment of 21 amino acids, and a cytoplasmic region of 124 amino acids. It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. Nectin-3 is also involved in the formation of cell-cell junctions, including adherens junctions and synapses.

NCBI and Uniprot Product Information

• NCBI GI #: 343168783
• NCBI GeneID: 25945
• NCBI Accession #: NP_001230215.1
• NCBI GenBank Nucleotide #: NM_001243286.1
• UniProt Accession #: Q9NQS3; Q6NVZ3; Q8NC05; Q8WVU4; Q9BVA9; Q9Y412; E9PFR0
• Molecular Weight: Molecular Mass: 35.0 kDa; Actual Protein Molecular Mass: 54 kDa
• NCBI Official Full Name: nectin-3 isoform 2
• NCBI Official Synonym Full Names: nectin cell adhesion molecule 3
• NCBI Official Symbol: NECTIN3
• NCBI Official Synonym Symbols: PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3
• NCBI Protein Information: nectin-3
• UniProt Protein Name: Nectin-3
• UniProt Gene Name: NECTIN3
• UniProt Synonym Gene Names: PRR3; PVRL3

NCBI Description

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.