NDuFS4 recombinant protein

NDuFS4, 43-175aa, Human, E Coli

Cat. Num. AAA203329

• Gene Names: NDUFS4; AQDQ; CI-18; CI-AQDQ; CI-18 kDa
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: NDuFS4; 43-175aa; Human; E Coli; NADH dehydrogenase (ubiquinone) Fe-S protein 4; AQDQ; NADH dehydrogenase (ubiquinone) Fe-S protein 4 CI 18 kDa; CI AQDQ; Complex I 18 kDa; Complex I AQDQ; mitochondrial respiratory chain complex I (18 KD subunit); NADH dehydrogenase; NADH ubiquinone oxidoreductase 18 kDa subunit.; NDuFS4 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 30% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK
• Sequence Length: 175

• Applicable Applications for NDuFS4 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for NDuFS4 recombinant protein

NDuFS4, also known as NADH dehydrogenase (ubiquinone) Fe-S protein 4, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. Recombinant human NDuFS4 protein was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for NDuFS4 recombinant protein

Metabolism

References

Choi WS., et al. (2008), Proc Natl Acad Sci u S A. 105 (39):15136-41.; De Rasmo D., et al. (2008). Cell Signal. 20 (5):989-97.;

NCBI and Uniprot Product Information

• NCBI GI #: 4505369
• NCBI GeneID: 4724
• NCBI Accession #: NP_002486
• NCBI GenBank Nucleotide #: NM_002495.3
• UniProt Accession #: O43181; Q9BS69
• Molecular Weight: 15.5 kDa (134aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: NADH dehydrogenase
• NCBI Official Synonym Full Names: NADH:ubiquinone oxidoreductase subunit S4
• NCBI Official Symbol: NDUFS4
• NCBI Official Synonym Symbols: AQDQ; CI-18; CI-AQDQ; CI-18 kDa
• NCBI Protein Information: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
• UniProt Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
• Protein Family: NADH dehydrogenase [ubiquinone] iron-sulfur protein
• UniProt Gene Name: NDUFS4
• UniProt Synonym Gene Names: CI-18 kDa; CI-AQDQ

NCBI Description

This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.