Mouse anti-Human, Rat SSTR3 Monoclonal Antibody | anti-SSTR3 antibody

Anti-SSTR3 Mouse mAb

Cat. Num. AAA476526

• Gene Names: SSTR3; SS3R; SS3-R; SS-3-R; SSR-28
• Reactivity: Human, Rat
• Applications: Western Blot, Flow Cytometry, Functional Assay
• Synonyms: SSTR3; Monoclonal Antibody; Anti-SSTR3 Mouse mAb; SS3R; SS3-R; SS-3-R; SSR-28; anti-SSTR3 antibody

• Host: Mouse
• Reactivity: Human, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7H8E5
• Form/Format: Purified antibody in PBS with 0.05% sodium azide.
• Sequence Length: 418

• Applicable Applications for anti-SSTR3 antibody: Western Blot (WB), Flow Cytometry (FC/FACS)
• Immunogen: Purified recombinant fragment of human SSTR3 (AA: 1-43) expressed in E Coli.

Western Blot (WB)

(Western blot analysis using SSTR3 mAb against human SSTR3 (AA)

Western Blot (WB)

(Western blot analysis using SSTR3 mAb against HEK293 (1) and SSTR3 (AA)

Western Blot (WB)

(Western blot analysis using SSTR3 mouse mAb against Hela (1), PANC-1 (2), PC-12 (3), SK-N-SH (4), U937 (5) and HepG2 (6) cell lysate.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of Hela cells using SSTR3 mouse mAb (green) and negative control (red).)

Related Product Information for anti-SSTR3 antibody

Entrez Summary: This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 4557861
• NCBI GeneID: 6753
• NCBI Accession #: NP_001042.1
• NCBI GenBank Nucleotide #: NM_001051.4
• UniProt Accession #: P32745; Q53ZR7; A8K550
• Molecular Weight: 45.8
• NCBI Official Full Name: somatostatin receptor type 3
• NCBI Official Synonym Full Names: somatostatin receptor 3
• NCBI Official Symbol: SSTR3
• NCBI Official Synonym Symbols: SS3R; SS3-R; SS-3-R; SSR-28
• NCBI Protein Information: somatostatin receptor type 3
• UniProt Protein Name: Somatostatin receptor type 3
• Protein Family: Somatostatin receptor
• UniProt Gene Name: SSTR3
• UniProt Synonym Gene Names: SS-3-R; SS3-R; SS3R

NCBI Description

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SSTR3: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide binding; protein binding

Biological Process: cell-cell signaling; G-protein signaling, coupled to cyclic nucleotide second messenger; induction of apoptosis by hormones; negative regulation of cell proliferation; synaptic transmission