Nucleoporin NDC1 (NDC1) Recombinant Protein | NDC1 recombinant protein
Recombinant Saccharomyces cerevisiae Nucleoporin NDC1 (NDC1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Functions as a component of the nuclear pore complex (NPC) and the spindle pole body (SPB), probably by playing a key role in de novo assembly and insertion of both structures in the nuclear envelope. In SPB duplication NDC1 is required for the insertion of the cytoplasmic side of the SPB in the nuclear envelope, thus allowing for the assembly of the nucleoplasmic SPB side. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Ref.4 Ref.7 Ref.12
Subunit structure: The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NDC1 may form a subcomplex with ASM4 and NUP53 at the NPC. Interactions at the SPB have not been determined. Ref.5
Subcellular location: Nucleus › nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Cytoplasm › cytoskeleton › spindle pole body. Note: Central core structure of the nuclear pore complex. Spindle pole body, central plaque.
Miscellaneous: Present with 3030 molecules/cell in log phase SD medium.
Sequence similarities: Belongs to the NDC1 family.
Research Articles on NDC1
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Product Notes
The NDC1 ndc1 (Catalog #AAA1148067) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-655. The amino acid sequence is listed below: MIQTPRELLN PRYTYHTIFS DVCKTRFNHL VTRLFFICSI IQTVVISLLA LPHSPLWELA LAFIPNILAL NLVSLLIIVT RKNYMHVKNF GFANSLTFIL GQLLSVKFLV YQGVYSMGSI LLSFVLGVVF GRGGSGWKPY YKLFIWLVVP TIYNLQHHVT DADKLSFNCE NFFQAPQDYV LERVKRIMEK SVILSVISMF VLPIFTTVFF SRQKSGLFDS FTNGVLAVTN LLIISCIIFI TFEFINIAFD AHMSIGCLHK GKLISNLSST PMETLLSGLS ADKPFTRLTA YQELAYRATS LDPSLRAPIY HSKFRSSSGN TWSLILNECL KTIQINNEKV VQYLRSVQDL GGSATARHKK KVENLDYMYE NGKLTSANER LFGNRPSMMA PLRDNGLLDE SPNRLRVRTD DSVLLNRGNK KRHRSSYYDN DLDETTQTFN GSIFTHETTF MTAMRLMLKK LKNSIMSFIF PSYAERQSSD ESDNYRLLPN GSNKAQISII DIWSISKKRQ AEKLVPLPIC HANSVVALTG LLIRSKTEDP KGGIIASVGD ILKTLERSIC ALGEFADWDP ESMAYTAFQT QRTAQDRVQQ DSEDEDSMKD TTDMISVLYQ LSTSAFMEIV LEYNVALNDV YLDADVAKLA NWFLEVYASG NPNAT. It is sometimes possible for the material contained within the vial of "Nucleoporin NDC1 (NDC1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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