Rat nicastrin ELISA Kit | NCSTN elisa kit
Rat Nicastrin, NCSTN ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
component of the gamma-secretase complex, which catalyzes the cleavage of amyloid precursor protein APP [RGD, Feb 2006]
Uniprot Description
nicastrin: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Constitutively expressed in neural cells. Widely expressed. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: Golgi apparatus; focal adhesion; membrane; lysosomal membrane; integral to plasma membrane; endoplasmic reticulum; plasma membrane; melanosome
Molecular Function: peptidase activity; protein binding; endopeptidase activity
Biological Process: positive regulation of catalytic activity; T cell proliferation; epithelial cell proliferation; Notch signaling pathway; beta-amyloid metabolic process; membrane protein ectodomain proteolysis; myeloid cell homeostasis; protein processing; proteolysis
Research Articles on NCSTN
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Product Notes
The Rat NCSTN ncstn (Catalog #AAA9342809) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342809 ELISA Kit recognizes Rat NCSTN. It is sometimes possible for the material contained within the vial of "nicastrin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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