Rat nuclear receptor coactivator 2 ELISA Kit | NCOA2 elisa kit
Rat Nuclear receptor coactivator 2, NCOA2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds to nuclear receptor complex leading to coactivation [RGD, Feb 2006]
Uniprot Description
SRC-2: a transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Present in a complex with CARM1 and p300. Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts with HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2. Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation. Phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: Golgi apparatus; microtubule; rough endoplasmic reticulum; cell soma; dendrite; postsynaptic density; cytoplasm; dendritic spine; presynaptic active zone; nucleus
Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; retinoic acid receptor binding; transcription coactivator activity; transcription factor binding; PDZ domain binding; thyroid hormone receptor coactivator activity; retinoid X receptor binding; signal transducer activity; histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; protein complex binding; estrogen receptor binding; thyroid hormone receptor binding; chromatin binding; progesterone receptor binding; glucocorticoid receptor binding; receptor binding; nuclear hormone receptor binding
Biological Process: locomotor rhythm; transcription, DNA-dependent; regulation of transcription, DNA-dependent; male gonad development; positive regulation of female receptivity; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; histone acetylation; signal transduction; negative regulation of transcription, DNA-dependent; cellular response to hormone stimulus
Research Articles on NCOA2
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Product Notes
The Rat NCOA2 ncoa2 (Catalog #AAA9316374) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316374 ELISA Kit recognizes Rat NCOA2. It is sometimes possible for the material contained within the vial of "nuclear receptor coactivator 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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