PAPPA native protein

PAPPA protein

Cat. Num. AAA5303551

• Gene Names: PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• Purity: > 80% pure
• Synonyms: PAPPA; PAPPA protein; ASBABP2 protein; Pappalysin 1 protein; PAPP A protein; IGFBP4ase protein; DIPLA1 protein; PAPP-A protein; Pregnancy Associated Plasma Protein A protein; PAPPA native protein

• Host: Human
• Purity/Purification: > 80% pure
• Form/Format: 0.2 micron filtered liquid, supplied in 10mM Tris-buffer, pH7.4, 0.15M NaCI, 0.09% Na Azide and 0.01% NGME
• Concentration: 4.3 mg/mL by ELISA ; Activity: 965.10 mIU/mL by Roche ECLIA (varies by lot)
• Sequence Length: 186

• Host Note: Human Placenta serum
• Protein Type: Native
• Biological Significance: Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome and more recently as a cardiac marker. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome.
• Biohazard Information: The material tested negative for HBsAg, anti-HCV and Anti-HIV 1&2 by currently approved methods. Use standard laboratory procedures when handling this product.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Upon receipt store at -20°C in working aliquots. Avoid repeated freeze/thaw cycles.

Related Product Information for PAPPA native protein

Purified native Human PAPPA protein

Product Categories/Family for PAPPA native protein

Cardiac Markers; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 55139852
• NCBI GeneID: 5069
• Molecular Weight: 180,973 Da
• NCBI Official Full Name: pregnacy-associated plasma protein A, partial
• NCBI Official Synonym Full Names: pregnancy-associated plasma protein A, pappalysin 1
• NCBI Official Symbol: PAPPA
• NCBI Official Synonym Symbols: PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• NCBI Protein Information: pappalysin-1
• UniProt Protein Name: Pappalysin-1
• Protein Family: Pappalysin
• UniProt Gene Name: PAPPA
• UniProt Synonym Gene Names: IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A
• UniProt Entry Name: PAPP1_HUMAN

NCBI Description

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

Uniprot Description

PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.24.79

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: membrane; extracellular region

Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; female pregnancy; proteolysis; cell differentiation