C-REACTIVE PROTEIN Native Protein | CRP native protein

NATIVE HUMAN C-REACTIVE PROTEIN

Cat. Num. AAA230094

• Gene Names: CRP; PTX1
• Applications: ELISA
• Purity: SDS PAGE: >96%
• Synonyms: C-REACTIVE PROTEIN; NATIVE HUMAN C-REACTIVE PROTEIN; CRP native protein

• Purity/Purification: SDS PAGE: >96%
• Form/Format: Purified; Purified protein from human plasma - liquid
• Concentration: Approximate Protein Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 91

• Applicable Applications for CRP native protein: ELISA (EIA)
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Buffer Solution: TRIS buffered saline
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 12 months from date of despatch.

Testing Data #1

(Native human C-reactive protein (MBS230094) detected with Mouse anti Human C-reactive protein followed by Rabbit F(ab')2 anti Mouse IgG:HRP (MBS235192))

Related Product Information for CRP native protein

C-reactive protein is an acute phase protein, produced by the liver that is used as a marker of inflammation and for monitoring and predicting coronary artery disease. It exists in the blood as a large pentamer of approximately 114 kDa.

NCBI and Uniprot Product Information

• NCBI GI #: 55770842
• NCBI GeneID: 1401
• NCBI Accession #: NP_000558.2
• NCBI GenBank Nucleotide #: NM_000567.2
• UniProt Accession #: P02741; Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
• Molecular Weight: 114 kDa
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1
• NCBI Protein Information: C-reactive protein; pentraxin 1
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Description

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; virion binding; low-density lipoprotein binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; wound healing; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging