Hamster Nicotinamide Adenine Dinucleotide Phosphate Oxidase Gp91Phox ELISA Kit | NADHPOX elisa kit
Hamster Nicotinamide Adenine Dinucleotide Phosphate Oxidase Gp91Phox ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Oxidoreductase; Membrane protein, integral; Cell cycle regulation; EC 1.6.3.-; Membrane protein, multi-pass
Cellular Component: focal adhesion; mitochondrion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; apical plasma membrane; stress fiber; integral to membrane; plasma membrane; cell junction; NADPH oxidase complex
Molecular Function: NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor; oxidoreductase activity
Biological Process: positive regulation of apoptosis; cell morphogenesis; superoxide metabolic process; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of stress fiber formation; superoxide release; bone resorption
Research Articles on NADHPOX
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Product Notes
The Hamster NADHPOX nox4 (Catalog #AAA029207) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA029207 ELISA Kit recognizes Hamster NADHPOX. It is sometimes possible for the material contained within the vial of "Nicotinamide Adenine Dinucleotide Phosphate Oxidase Gp91Phox, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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