NAALADL1 recombinant protein

NAALADL1 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8123040

• Gene Names: Naaladl1; Gm964; Naaladasel
• Purity: >97% as determined by SDS-PAGE
• Synonyms: NAALADL1; NAALADL1 Protein; Mouse; Recombinant (His Tag); Mouse NAALADL1 Protein (His Tag); Gm964 Protein; Naaladasel Protein; N-acetylated alpha-linked acidic dipeptidase-like 1; NAALADL1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >97% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Pro29-Leu745

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the secreted form of mouse NAALADL1 (Q7M758)(Pro 29-Leu 745) was fused with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for NAALADL1 recombinant protein

Background: N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus, and ventral striatum. NAALADase L is a chloride-activated, membrane-bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

References

Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300. Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15. Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83. Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.

NCBI and Uniprot Product Information

• NCBI GI #: 57222282
• NCBI GeneID: 381204
• NCBI Accession #: NP_001009546.1
• NCBI GenBank Nucleotide #: NM_001009546.1
• UniProt Accession #: Q7M758
• Molecular Weight: 80,513 Da
• NCBI Official Full Name: N-acetylated-alpha-linked acidic dipeptidase-like protein
• NCBI Official Synonym Full Names: N-acetylated alpha-linked acidic dipeptidase-like 1
• NCBI Official Symbol: Naaladl1
• NCBI Official Synonym Symbols: Gm964; Naaladasel
• NCBI Protein Information: N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; N-acetylated-alpha-linked acidic dipeptidase like protein
• UniProt Protein Name: N-acetylated-alpha-linked acidic dipeptidase-like protein
• Protein Family: N-acetylated-alpha-linked acidic dipeptidase-like protein
• UniProt Gene Name: Naaladl1
• UniProt Synonym Gene Names: Gm964; Naaladasel; NAALADase L
• UniProt Entry Name: NALDL_MOUSE