Neuraminidase (NA) Recombinant Protein | NA recombinant protein
Recombinant Influenza A virus Neuraminidase (NA)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
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Product Notes
The NA na (Catalog #AAA7022613) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-469aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the NA na for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MNPNQKIITI GSVSLTIATI CFLMQIAILV TTVTLHFKQY ECDSPANNQV MPCEPIIIER NITEIVYLTN TTIEKEICPK LVEYRNWSKP QCKITGFAPF SKDNSIRLSA GGDIWVTREP YVSCDPGRCY QFALGQGTTL DNKHSNDTIH DRTPHRTLLM NELGVPFHLG TRQVCIAWSS SSCHDGKAWL HVCVTGYDKN ATASFIYDGR LVDSIGSWSK NILRTQESEC VCINGTCTVV MTDGSASERA DTKVLFIEEG KIVHISPLSG SAQHVEECSC YPRYPGVRCV CRDNWKGSNR PVVDINVKDY SIASSYVCSG LVGDTPRKND RYSSSYCRNP NNEKGNHGVK GWAFDDGNDV WMGRTISDES RSGYETFKVI GGWSTPNSKL QINRQVIVDS DNRSGYSGIF SVEGKSCINR CFYVELIRGR EQETRVWWTS NSIVVFCGTS GTYGTGSWPD GADINLMPI. It is sometimes possible for the material contained within the vial of "Neuraminidase (NA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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