Human myosin XVA ELISA Kit | MYO15A elisa kit
Human Myosin-XV, MYO15A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
MYO15A: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles. Defects in MYO15A are the cause of deafness autosomal recessive type 3 (DFNB3). DFNB3 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: stereocilium; cytoplasm; myosin complex
Molecular Function: calmodulin binding; motor activity; actin binding; ATP binding
Biological Process: inner ear morphogenesis; sensory perception of sound; metabolic process; locomotory behavior
Disease: Deafness, Autosomal Recessive 3
Research Articles on MYO15A
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Product Notes
The Human MYO15A myo15a (Catalog #AAA9319976) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319976 ELISA Kit recognizes Human MYO15A. It is sometimes possible for the material contained within the vial of "myosin XVA, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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