NCBI Description
This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
Uniprot Description
MRLC3: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 18p11.31
Cellular Component: myosin II complex; stress fiber; Z disc; cytosol
Molecular Function: glutamate receptor binding; protein binding; calcium ion binding
Biological Process: axon guidance; regulation of cell shape; ephrin receptor signaling pathway
Product Notes
The Human MYL12A myl12a (Catalog #
AAA9339942) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339942 ELISA Kit recognizes Human MYL12A.
It is sometimes possible for the material contained within the vial of
"myosin, light chain 12A, regulatory, non-sarcomeric, ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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