Methylmalonyl-CoA mutase, mitochondrial (Mutc) Recombinant Protein | Mutc recombinant protein

Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial (Mutc)

Cat. Num. AAA9424015

• Gene Names: Mut; Mcm; D230010K02Rik
• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Methylmalonyl-CoA mutase; mitochondrial (Mutc); Recombinant Mouse Methylmalonyl-CoA mutase; Methylmalonyl-CoA isomerase; Mut; Mutc recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Full Length, 31-748aa
• Sequence: LHQQQPLHPEWAVLAKKQLKGKNPEDLIWHTPEGISIKPLYSRADTLDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVNKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTRIPRAAVQVLDDIEKCLAEKQQSV

• Tag Info: N-terminal 6xHis-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; ; Generally, the shelf life of liquid form is 6 months at -20°C,-80°C. The shelf life of lyophilized form is 12 months at -20°C,-80°C.Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

SDS-PAGE

Related Product Information for Mutc recombinant protein

Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle.

NCBI and Uniprot Product Information

• NCBI GI #: 148540106
• NCBI GeneID: 17850
• NCBI Accession #: NP_032676.2
• NCBI GenBank Nucleotide #: NM_008650.3
• UniProt Accession #: P16332; Q3UJU1
• Molecular Weight: 83.2kDa
• NCBI Official Full Name: methylmalonyl-CoA mutase, mitochondrial
• NCBI Official Synonym Full Names: methylmalonyl-Coenzyme A mutase
• NCBI Official Symbol: Mut
• NCBI Official Synonym Symbols: Mcm; D230010K02Rik
• NCBI Protein Information: methylmalonyl-CoA mutase, mitochondrial
• UniProt Protein Name: Methylmalonyl-CoA mutase, mitochondrial
• UniProt Gene Name: Mut
• UniProt Synonym Gene Names: MCM

Uniprot Description

MUT: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. Defects in MUT are the cause of methylmalonic aciduria type mut (MMAM). MMAM is an often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MMAM is unresponsive to vitamin B12 therapy. Belongs to the methylmalonyl-CoA mutase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; EC 5.4.99.2; Isomerase; Mitochondrial

Chromosomal Location of Human Ortholog: 17 B2|17 19.55 cM

Cellular Component: mitochondrion

Molecular Function: methylmalonyl-CoA mutase activity

Biological Process: homocysteine metabolic process; post-embryonic development