Methylmalonyl-CoA mutase Recombinant Protein | Mut recombinant protein

Recombinant Mouse Methylmalonyl-CoA mutase, mitochondrial

Cat. Num. AAA967505

• Gene Names: Mut; Mcm; D230010K02Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Methylmalonyl-CoA mutase; Recombinant Mouse Methylmalonyl-CoA mutase; mitochondrial; Methylmalonyl-CoA isomerase; Mut recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 31-748aa; Full Length
• Sequence: LHQQQPLHPEWAVLAKKQLKGKNPEDLIWHTPEGISIKPLYSRADTLDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVNKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTRIPRAAVQVLDDIEKCLAEKQQSV
• Sequence Length: 748

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Mut recombinant protein

Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle.

Product Categories/Family for Mut recombinant protein

Metabolism

References

"Primary structure and activity of mouse methylmalonyl-CoA mutase." Wilkemeyer M.F., Crane A.M., Ledley F.D. Biochem. J. 271:449-455(1990)

NCBI and Uniprot Product Information

• NCBI GI #: 148540106
• NCBI GeneID: 17850
• NCBI Accession #: NP_032676.2
• NCBI GenBank Nucleotide #: NM_008650.3
• UniProt Accession #: P16332; Q3UJU1
• Molecular Weight: 80.5 kDa
• NCBI Official Full Name: methylmalonyl-CoA mutase, mitochondrial
• NCBI Official Synonym Full Names: methylmalonyl-Coenzyme A mutase
• NCBI Official Symbol: Mut
• NCBI Official Synonym Symbols: Mcm; D230010K02Rik
• NCBI Protein Information: methylmalonyl-CoA mutase, mitochondrial
• UniProt Protein Name: Methylmalonyl-CoA mutase, mitochondrial
• Protein Family: Methylmalonyl-CoA mutase
• UniProt Gene Name: Mut
• UniProt Synonym Gene Names: MCM
• UniProt Entry Name: MUTA_MOUSE

Uniprot Description

MUT: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. Defects in MUT are the cause of methylmalonic aciduria type mut (MMAM). MMAM is an often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MMAM is unresponsive to vitamin B12 therapy. Belongs to the methylmalonyl-CoA mutase family.

Protein type: Carbohydrate Metabolism - propanoate; EC 5.4.99.2; Isomerase; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Cellular Component: mitochondrion

Molecular Function: catalytic activity; cobalamin binding; intramolecular transferase activity; isomerase activity; metal ion binding; methylmalonyl-CoA mutase activity

Biological Process: homocysteine metabolic process; metabolic process; post-embryonic development