Muscle, skeletal receptor tyrosine protein kinase (MUSK) Recombinant Protein | MUSK recombinant protein

Recombinant Chicken Muscle, skeletal receptor tyrosine protein kinase (MUSK), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Muscle; skeletal receptor tyrosine protein kinase (MUSK); Recombinant Chicken Muscle; partial; MUSK recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 947

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 45383894
• NCBI GeneID: 373897
• NCBI Accession #: NP_989439.1
• NCBI GenBank Nucleotide #: NM_204108.1
• UniProt Accession #: Q8AXY6
• Molecular Weight: 105,589 Da
• NCBI Official Full Name: muscle, skeletal receptor tyrosine protein kinase
• NCBI Official Synonym Full Names: muscle associated receptor tyrosine kinase
• NCBI Official Symbol: MUSK
• NCBI Protein Information: muscle, skeletal receptor tyrosine protein kinase
• UniProt Protein Name: Muscle, skeletal receptor tyrosine protein kinase
• Protein Family: Muscle, skeletal receptor tyrosine protein kinase
• UniProt Gene Name: MUSK
• UniProt Synonym Gene Names: MuSK; Muscle-specific kinase receptor

Uniprot Description

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation ().