Human male-specific lethal 3 homolog (Drosophila) ELISA Kit | MSL3 elisa kit
Human Male-specific lethal 3 homolog, MSL3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Uniprot Description
MSL3L1: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; transcription factor activity; methylated histone residue binding
Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; multicellular organismal development
Research Articles on MSL3
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Product Notes
The Human MSL3 msl3 (Catalog #AAA9338100) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338100 ELISA Kit recognizes Human MSL3. It is sometimes possible for the material contained within the vial of "male-specific lethal 3 homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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