Lipid A export ATP-binding/permease protein MsbA (msbA) Recombinant Protein | msbA recombinant protein

Recombinant Escherichia coli Lipid A export ATP-binding/permease protein MsbA (msbA)

• Gene Names: msbA; ECK0905; JW0897
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lipid A export ATP-binding/permease protein MsbA (msbA); Recombinant Escherichia coli Lipid A export ATP-binding/permease protein MsbA (msbA); Recombinant Lipid A export ATP-binding/permease protein MsbA (msbA); Lipid A export ATP-binding/permease protein MsbA EC= 3.6.3.-; msbA recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-582
• Sequence: MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ
• Sequence Length: 582

• Species: Escherichia coli (strain K12)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 16128881
• NCBI GeneID: 945530
• NCBI Accession #: NP_415434.1
• NCBI GenBank Nucleotide #: NC_000913.2
• UniProt Accession #: P60752; P27299
• Molecular Weight: 64,461 Da
• NCBI Official Full Name: fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component
• NCBI Official Symbol: msbA
• NCBI Official Synonym Symbols: ECK0905; JW0897
• NCBI Protein Information: fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component
• UniProt Protein Name: Lipid A export ATP-binding/permease protein MsbA
• Protein Family: Lipid A export ATP-binding/permease protein
• UniProt Gene Name: msbA
• UniProt Entry Name: MSBA_ECOLI

NCBI Description

MsbA PDB structures 1JSQ, 1PF4 and 1Z2R, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006). [More information is available at EcoGene: EG10613]. Lipid A serves as a hydrophobic membrane anchor for the lipopolysaccharide, which is a major component of the outer leaflet of the outer membranes of Gram-negative bacteria. [More information is available at EcoCyc: EG10613].

Uniprot Description

Function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

Subunit structure: Homodimer

By similarity.

Subcellular location: Cell inner membrane; Multi-pass membrane protein Ref.7 Ref.9.

Domain: In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similarities: Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.