High affinity immunoglobulin epsilon receptor subunit beta (Ms4a2) Recombinant Protein | Ms4a2 recombinant protein

Recombinant Rat High affinity immunoglobulin epsilon receptor subunit beta (Ms4a2)

• Gene Names: Ms4a2; FCIGA; Ms4a1; Fcer1b
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: High affinity immunoglobulin epsilon receptor subunit beta (Ms4a2); Recombinant Rat High affinity immunoglobulin epsilon receptor subunit beta (Ms4a2); Recombinant High affinity immunoglobulin epsilon receptor subunit beta (Ms4a2); High affinity immunoglobulin epsilon receptor subunit beta; FcERI; Fc epsilon receptor I beta-chain IgE Fc receptor subunit beta Membrane-spanning 4-domains subfamily A member; Ms4a2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-243
• Sequence: MDTENKSRADLALPNPQESPSAPDIELLEASPPAKALPEKPASPPPQQTWQSFLKKELEFLGVTQVLVGLICLCFGTVVCSTLQTSDFDDEVLLLYRAGYPFWGAVLFVLSGFLSIMSERKNTLYLVRGSLGANIVSSIAAGLGIAILILNLSNNSAYMNYCKDITEDDGCFVTSFITELVLMLLFLTILAFCSAVLLIIYRIGQEFERSKVPDDRLYEELHVYSPIYSALEDTREASAPVVS
• Sequence Length: 243

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6978835
• NCBI GeneID: 25316
• NCBI Accession #: NP_036977.1
• NCBI GenBank Nucleotide #: NM_012845.1
• UniProt Accession #: P13386
• Molecular Weight: 26,731 Da
• NCBI Official Full Name: high affinity immunoglobulin epsilon receptor subunit beta
• NCBI Official Synonym Full Names: membrane-spanning 4-domains, subfamily A, member 2
• NCBI Official Symbol: Ms4a2
• NCBI Official Synonym Symbols: FCIGA; Ms4a1; Fcer1b
• NCBI Protein Information: high affinity immunoglobulin epsilon receptor subunit beta; fcERI; beta polypeptide); IgE Fc receptor subunit beta; fc epsilon receptor I beta-chain; Membrane-spanning 4-domains subfamily A member 1; Membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
• UniProt Protein Name: High affinity immunoglobulin epsilon receptor subunit beta
• Protein Family: High affinity immunoglobulin epsilon receptor
• UniProt Gene Name: Ms4a2
• UniProt Synonym Gene Names: Fce1b; Fcer1b; FcERI
• UniProt Entry Name: FCERB_RAT

NCBI Description

beta chain of the high affinity receptor for immunoglobulin E [RGD, Feb 2006]

Uniprot Description

FcER1B: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Cellular Component: integral to plasma membrane; Fc-epsilon receptor I complex; endosome; lipid raft; external side of plasma membrane

Molecular Function: phosphoprotein binding; SH2 domain binding; IgE binding; protein kinase binding; IgE receptor activity

Biological Process: cell surface receptor linked signal transduction; phospholipase C activation; protein kinase C activation; positive regulation of mast cell degranulation; immune response; signal transduction; inflammatory response; cytokine secretion; regulation of release of sequestered calcium ion into cytosol